Our Mission

Massive macromolecular complexes are essential in numerous cellular processes, including transcription, translation, splicing, nuclear import/export, metabolism, and degradation. Notably, errors in these assembly and disassembly processes dysregulate cellular homeostasis and have been linked to a variety of diseases.

We are actively working to uncover how these complexes are assembled, disassembled, and degraded, and to learn how environmental stress, mutations, disease, and aging alter the fidelity of these processes. Additionally, we contend that learning the assembly principles of natural macromolecular complexes can guide efforts to build ever larger synthetic molecular machines with applications in metabolic engineering, drug delivery, and materials science.


The construction of an airplane is simple compared with the evolutionary achievement of a bird. If I had to choose, I would rather have birds than airplanes.
— Charles Lindbergh