Today the Royal Swedish Academy of Sciences announced that the 2017 prize in Chemistry was awarded to Joachim Frank, Richard Henderson, and Jacques Dubochet for "developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution." CryoEM is a truly transformative technology perfectly suited to study macromolecular machines. The Davis lab uses this technique regularly and we're excited to take advantage of MIT's recent investments in the space.
Check out this lovely flowchart of Joachim Frank's widely used approach to generate 3D electron density maps from 2D micrographs.